The warts have the appearance of thick, scaly skin. They can occur as small, single warts or can cluster into large areas. These clustered warts are called mosaic warts. They often resemble plantar calluses. A simple way to tell the difference between a wart and a callus is to squeeze the lesion between your fingers in a pinching fashion. If this is painful, it is likely that the lesion is a wart. A callus is generally not painful with this maneuver but is tender with direct pressure by pressing directly on the lesion. Other lesions on the bottom of the foot that are often confused with plantars warts are porokeratoses and inclusion cysts.
There are a variety of ways to treat warts. The over-the-counter medications have a difficult time penetrating the thick skin on the bottom of the foot, so they do not work well in this area. Professional treatment consists of burning the wart with topical acids, freezing with liquid nitrogen, laser surgery or cutting them out. All methods have the possibility of the wart coming back. Surgical excision of the wart has the highest success rate with a relatively low rate of recurrence. There is some mild discomfort with this procedure and it takes several weeks for the area to completely heal. Normal activity can generally be resumed in a few days depending on the size and number of warts that have been removed. The risks associated with surgical removal of warts are the possibility of infection, or the formation of a scar, which can be painful when weight is applied while walking.
Laser removal of the wart works by burning the wart with a laser beam. The area must be numbed with an anesthetic prior to the procedure. There is little advantage to removing warts with a laser unless the warts are very large (mosaic warts) or there are a large number to be removed. The risks associated with the use of the laser are the same as for cutting the warts out. These risks include infection and the development of a scar after healing. A new type of laser has been developed to treat several different types of skin lesions called the Pulsed Dye Laser. This new laser has promise in the effective treatment of warts.
Freezing the wart with liquid nitrogen is another form of treatment. This form of treatment when the warts are on the bottom of the foot can be very painful and take several days or weeks to heal.
Topical acids can also be a useful means of treating warts. The advantage to this form of treatment is the fact that they are nearly painless and there is no restriction of activity. The down side to this form of treatment is that it frequently requires several treatments and the failure rate is higher than surgical excision of the wart.